For longevity medicine partners

The foundational layer of longevity your stack is missing.

Meo trains the nervous system directly — so every other intervention in your protocol compounds.

Become a partner → See the evidence
Validated by
Mount Sinai
Evidence base
58+ RCTs
Mortality lever
−20% per 10 ms SDNN
Patient time
10 minutes a day
Built on research from leading academic medical centers
Mount Sinai USC UCLA UC Irvine Stanford Harvard
The Thesis

The body cannot recover in survival mode.

Longevity stacks are sophisticated at the top — diagnostics, pharmacology, peptides, IV. But none of it works on a dysregulated nervous system. Three reasons HRV training is foundational.

01
Every therapy needs autonomic balance.
Rapamycin, peptides, NAD+, HRT, and structured sleep protocols all underperform when patients are locked in chronic sympathetic dominance. Repair is parasympathetically gated.
02
HRV is the cleanest signal of that balance.
HRV declines faster with age than any other biomarker — about 80% between age 20 and 60. It is also the most behaviorally modifiable autonomic measure available.
03
Nothing else in the stack targets it.
Of the standard longevity interventions, none directly train autonomic regulation. Meo occupies the foundational layer beneath the existing stack.
How it works

One pathway. Every biomarker. The vagus nerve.

Resonance-frequency breathing (~6 bpm) maximizes baroreflex gain and vagal afferent traffic. This single neural mechanism cascades through the entire longevity biomarker stack.

01 · Begin
Paced breathing
Patient breathes at individualized resonance frequency (4.5–6.5 bpm) with real-time biofeedback.
02 · Train
Baroreflex engagement
Large heart rate oscillations strengthen the baroreflex over 4–12 weeks of daily practice.
03 · Signal
Vagal afferents
Vagal tone rises, measurable via SDNN, HF-HRV, RMSSD on standard wearables and clinical recordings.
04 · Cascade
Cholinergic reflex
Splenic acetylcholine inhibits TNF-α, IL-6, IL-1β — the Tracey anti-inflammatory pathway.
05 · Cascade
Downstream effects
HPA modulation, β-adrenergic reduction, plasma amyloid clearance — the longevity cascade.
The Mortality Lever

HRV is a survival metric.

The Bilchick mortality curve has been replicated across longitudinal cohorts since 2002. Each 10 ms gain in SDNN corresponds to roughly a 20% reduction in all-cause mortality risk.

Figure 01
Mortality risk decreases steeply as SDNN rises across the clinical range.
5× 3× 2× 1.5× 1× UNHEALTHY COMPROMISED HEALTHY SDNN < 50 SDNN 50–100 SDNN > 100
Adapted from Bilchick et al., Am J Cardiol (2002).
−20%
All-cause mortality reduction per 10 ms increase in SDNN, replicated across longitudinal cohorts since 2002.
5×
Hazard ratio for early mortality in patients with SDNN < 19 ms — confirmed in centenarians (Hernández-Vicente, 2020).
+15–40%
SDNN improvement in 4–12 weeks of HRV biofeedback — sufficient to shift patients from unhealthy to healthy range in one quarter.
+45%
HRV gain in 4 weeks when patients consistently reach Zone 3 during daily Meo sessions. Internal cohort, 2025.
Effects across the stack

Nine biomarkers move when HRV moves.

Because HRV biofeedback acts upstream of multiple cascades, training elevations in vagal tone produce measurable change across the biomarkers your clinic already tracks.

Autonomic age
HRV (SDNN)
+15–40%
Direct mortality predictor. Each 10 ms increase = 20% reduction in all-cause mortality risk.
Bilchick 2002 · Petrowski 2023 RCT
Inflammaging
TNF-α, IL-6, hs-CRP
↓ significant
Direct cytokine reduction via cholinergic anti-inflammatory pathway in randomized trial.
Petrowski 2023 RCT · Jarczok meta
Alzheimer's risk
Plasma Aβ40 / 42
↓ large effect
The only behavioral intervention shown to reduce plasma amyloid-β. Exercise has not.
Min & Mather 2023 · n=108
HPA axis
Cortisol
↓ acute + chronic
Modulates HPA reactivity, reducing cortisol that drives visceral adiposity and insulin resistance.
Multiple RCTs
Cardiovascular
Blood pressure
↓ sys + dias
Effect comparable to a single antihypertensive across 20 RCTs and ~1,500 participants.
Jenkins 2024 meta-analysis
Recovery
Sleep quality
d = 0.99
Very large effect on Pittsburgh Sleep Quality Index after 4 weeks of daily practice.
Herhaus 2022, Front Physiol
Brain aging
Cortical volume
structural Δ
5 weeks of HRVB produces measurable cortical volume changes in PFC emotion-regulation regions.
Yoo & Nashiro 2022
Metabolic
HbA1c / glucose
↓ HbA1c
Emerging RCT evidence in prediabetes. Stacks cleanly with GLP-1 and metformin protocols.
Herhaus 2025
Mental health
Depression / anxiety
g = 0.38–0.41
Medium effect across 18 RCTs and 1,352 patients. No SSRI side-effect profile.
Pizzoli 2021 · 2025 meta
How we compare

Other tools claim nervous system support. Meo delivers it.

Compared head-to-head against meditation apps, biofeedback alternatives, and clinical vagus nerve stimulators on the three metrics that matter to a longevity clinic: clinical efficacy, patient compliance, and total cost.

Criterion Meo Vagus nerve stimulators Biofeedback apps Meditation apps
Clinical efficacy
measured in HRV gain 		+45%
Best in class		 Moderate Comparable Minimal
Compliance
daily adherence rate 		High High High Low
Price
cost to patient or clinic 		Low High High Low
+45%
HRV gain — matched only by clinical biofeedback and 6× higher than meditation apps.
High
Adherence — meditation apps lose patients in weeks; Meo's structured 90-day protocol holds them.
Low
Cost — clinical biofeedback and VNS run $thousands; Meo delivers comparable efficacy at a fraction.
Clinical Validation
Validated by Mount Sinai.

Meo's nervous system training protocol was tested at the Icahn School of Medicine at Mount Sinai — one of the most cited academic medical centers in the United States. After completing the protocol, patients showed measurable improvements in HRV trajectory, parasympathetic tone, and patient-reported symptom severity across 12 weeks.

Study site
Icahn School of Medicine at Mount Sinai
Publication
Frontiers in Rehab Sci, 2024
Regulatory
NIH submitted · FDA Class I exempt
92%
of patients reported meaningful autonomic and symptom improvement.
Traction

Doctors from world-leading health systems prescribe Meo.

Clinicians at academic medical centers across the US, Canada, UK, and Germany already refer patients to Meo as part of their nervous system and recovery protocols.

UCSF
Harvard
NHS
McGill
Cleveland Clinic
CharitéBerlin
Penn Medicine
UCLA
Johns Hopkins
Stanford
Mount Sinai
Mayo Clinic
Product

A daily practice your patients actually keep.

Meo delivers daily nervous system training through a patient app paired with an armband for continuous HRV monitoring, plus a clinician dashboard for population intelligence.

Patient · Daily practice
10 minutes a day. AI-coached.
A 90-day structured nervous system protocol with progressive resonance breathing curriculum and AI coaching that adapts to each patient's HRV trajectory.
Today's session
Resonance breathing · Day 28
+45%Zone 3
Zone 130%
Zone 378%
Zone 512%
Clinician · Population view
Population HRV intelligence.
Per-patient HRV trajectory, symptom signal tracking, 12-week program compliance, and a roster view across all enrolled patients.
Meo · Clinician dashboard
Cohort HRV trajectory
42 active patients · last 12 weeks
+34%SDNN
91%Adherence
72dMedian
M. Chen+38%
A. Patel+29%
S. Müller+22%
Partnership terms

Two ways to bring Meo into your practice.

Both tiers include the patient app, armband for continuous monitoring, AI biofeedback coach, and clinician dashboard. Choose the integration that fits your operating model.

Recommended
Tier 01 — Foundation
Patient License
Bundle Meo into your existing longevity membership as a prescribed daily protocol.
$450 $350 / patient / year
Limited-time promotional rate · Wearable included
Full Meo platform with armband for continuous HRV monitoring
AI biofeedback coach + 90-day personalized program
Patient dashboard delivered to your EHR or coaching workflow
Clinician-facing adherence and biomarker trend reports
Become a partner →
Tier 02 — Longevity Partnership
Clinic White-Label
Meo embedded as your clinic's signature nervous-system intervention, fully co-branded.
Custom
Designed for longevity clinics
Everything in Patient License, plus:
White-labeled app and patient portal under your brand
Clinical training for your medical team + continuing education
Quarterly biomarker correlation reports (HRV vs. your panels)
Co-published outcomes case studies — clinical marketing assets
Priority roadmap input and dedicated partnership manager
Connection to Heads Up monitoring platform
Talk to partnerships →

Let's build the foundational layer of longevity medicine.

We're partnering with a small number of leading longevity clinics in 2026 to co-develop the integration, measure cross-biomarker impact, and publish joint outcomes.

Become a partner → Visit meohealth.com